Neuroscience Research

 Lithium, Risperidone, ECT are standard treatments for mania. They are hypothesized to normalize a dysregulated monoamine homeostasis in psychosis.  Yet, the exact changes in monoamine homeostasis both in disease and health is still unclear, due to  (a) Inadequate resolution of tools used 
(b) Supratherapeutic drug doses in animal models not in keeping with clinically relevant dosing
(c) Animal studies being very brief and focused on acute changes (hours, days) rather than chronic drug dosing (months)

My research seeks to bridge basic neuroscience research with clinical realities by studying effects of drugs that are first line in management, given at clinically relevant doses for clinically relevant durations. The tools used include - STORM to photograph dopamine and glutamate receptors at a single molecule resolution, LC-MS to detect monoamine levels, RNA sequencing to detect intraneuronal changes.

The project is modelled after RDOC and involves investigations at multiple orders of magnitude - behavior, brain regions, dendritic spines, receptor proteins at the synapse and intra cellular targets.

 

Please visit the website of AD lab for more information - https://www.tifrh.res.in/~adishd/